This is basically reposting info from the V1 thread, but should include info relavent to WHS2011 (aka if you have tips/tricks/insights, please post here and I'll periodically update the post).
So here goes:
So here goes:
For the NIC:
Flow control: on (client and server)
"checksum" or "Offload": Off (client and server)
jumbo frames: off or default (client or server)
run "netsh interface tcp set global autotuninglevel=highlyrestricted" in an elevated console (command prompt) on *all* computers (Vista/Win7/Server 2008(R2)/WHS2011/SBS2011e)
Services/programs:
Windows Media Player Network Sharing Service: Disabled/manual
Windows Search Service: Disabled (and probably a good idea to move it to another drive anyhow, or at least d:\)
Install the "Remote Differential Compression" feature on the server, or uninstall it from all Win7/WHS2011 computers
Misc:
Run chkdsk on all the disks. Full is best, but just to make sure
Defrag.